Synthesis and Characterization of HPMpFBP Using Raman Spectroscopy, Nuclear Magnetic Resonance (NMR) Spectroscopy, and FTIR
DOI:
https://doi.org/10.25077/jif.13.2.109-117.2021Abstract
Synthesis is one of the models for the formation of a new drug or compound with the aim of obtaining better activity at an economical price. HPMpFBP has been synthesized by mixing of 1-phenyl-3-methyl-5-pyrazolone and 4-fluorobenzoyl chloride. In the synthesis of HPMpFBP, a new compound namely 1-phenyl-3-methyl-4-(4-fluorobenzoyl)-5-pyrozolone has been obtained. The sample then characterized by non-invasive methods using Raman spectroscopy, Nuclear Magnetic Resonance (NMR) Spectroscopy and FTIR. Through this characterization process, wavelength information, chemical shift, and functional groups (chemical structure) of HPMpFBP samples were obtained. HPMpFBP has a chemical structure of C17H13N2O2F, the highest wavelength carried out by characterization using Raman is 1643.91 cm-1, the highest chemical shift characterized by using NMR (Nuclear Magnetic Resonance) is 7.8628 ppm, and the functional groups identified by using FTIR are (O-H, C-H, C=C, C=O, C-N). Information from the HPMpFBP sample characterization process using mentioned characterization methods was compared with previously reported results.
Downloads
References
Asnawati, A., Indarti, D., & Mulyono, T. (2013). Amperometric biosensor for glucose detection based-on immobilisation of glucose oxidase in acetic cellulose membrane using ferrocene as mediator. Jurnal Ilmu Dasar, 14(1), 45–51.
Dachriyanus, P. D. (2004). Structural Analysis of Organic Compounds by Spectroscopy. LPTIK Andalas University.
Fatimura, M. (2017). Tinjauan Teoritis Faktor-Faktor Yang Mempengaruhi Operasi Pada Kolom Destilasi. Jurnal Media Teknik, 11(1).
Holze, R. (2007). E. Smith and G. Dent (eds): Modern Raman spectroscopy—a practical approach, Wiley, Chichester, United Kingdom, 2005, 210 + XI p., 24.95 £; ISBN 0471497940. Journal of Solid State Electrochemistry, 11(4). https://doi.org/10.1007/s10008-005-0062-2
Hore, P. J. (2015). Nuclear magnetic resonance. Oxford University Press, USA.
Jensen, B. S., Meier, H., Lundquist, K., & Refn, S. (1959). The Synthesis of 1-Phenyl-3-methyl-4-acyl-pyrazolones-5. Acta Chemica Scandinavica, 13. https://doi.org/10.3891/acta.chem.scand.13-1668
Lau, W. S. (2011). Infrared Characterization for Microelectronics. In Infrared Characterization for Microelectronics. https://doi.org/10.1142/9789812817464
Meera, R., & Reddy, M. L. P. (2004). Para-substituted 1-phenyl-3-methyl-4-aroyl-5-pyrazolones as chelating agents for the synergistic extraction of thorium(IV) and uranium(VI) in the presence of various crown ethers. Solvent Extraction and Ion Exchange, 22(5). https://doi.org/10.1081/SEI-200030290
Mohd Yazid, S. N. A., Md Isa, I., Abu Bakar, S., Hashim, N., & Ab Ghani, S. (2014). A review of glucose biosensors based on graphene/metal oxide nanomaterials. Analytical Letters, 47(11), 1821–1834.
Mustaffa, A., & Illyas Md Isa., M. I. S. (2011). Determination of Stability of Lanthanide Complexes La(III), Pr(III), Eu(III), Ga(III), Er(III), and Lu(III) with Fluorine 1-phenyl-3- methyl-4-benzoyl-5-pyrozolone (HPMBP) using imaging methods. J. Sains Dan Matematik, 3(2), 1–10.
Petrova, M. A., Kurteva, V. B., & Lubenov, L. A. (2011). Synergistic effect in the solvent extraction and separation of lanthanoids by 4-(4-fluorobenzoyl)-3-methyl-1-phenyl-pyrazol-5-one in the presence of monofunctional neutral organophosphorus extractants. Industrial & Engineering Chemistry Research, 50(21), 12170–12176.
Purwanto, B. T. (2013). Modifikasi Struktur N-Fenilurea Menjadi Senyawa Baru N-Benzoilfenilurea dan 4-Fluorobenzoilfenilurea Serta Uji Aktivitasnya sebagai Penekan Susunan Saraf Pusat. Majalah Berkala Ilmiah Kimia Farmasi, Departemen Kimia Farmasi FF Unair, 2(1), 28–32.
Remya, P. N., Ambili Raj, D. B., & Reddy, M. L. P. (2006). Para-substituted 1-phenyl-3-methyl-4-aroyl-5-pyrazolones as selective extractants for vanadium(V) from acidic chloride solutions. Solvent Extraction and Ion Exchange, 24(6).
https://doi.org/10.1080/07366290600952576
Saleh, M. I., Ahmad, M., & Darus, H. (1990). Solvent extraction of lanthanum (III), europium (III) and lutetium (III) with fluorinated 1-phenyl-3-methyl-4-benzoyl-5-pyrazolones into chloroform. Talanta, 37(7), 757–759.
Sastrohamidjojo, H. (2001). Spectroscopy. Yogyakarta: Liberty Yogyakarta.
Utamiyanti, I. F., Rumhayati, B., & Mulyasuryani, A. (2016). THE DEVELOPMENT OF GLUCOSE SENSOR BASED ON SiO2-CuO MATERIALS USING SCREEN PRINTED CARBON ELECTRODE (SPCE). ALCHEMY Jurnal Penelitian Kimia, 12(1), 50–60.
Wahyuono, R. A., Roekmono, R., Hadi, H., Yuwono, R. A., & Muhimmah, L. C. (2017). Deteksi Kadar Glukosa Dalam Plasma Darah Terpisah Oleh Mikrofluida Terintegrasi Partikel Nano ZnO Berbasis Spektroskopi Inframerah Dan Raman. Jurnal Integrasi Proses, 6(4), 148–154.
Downloads
Published
How to Cite
Issue
Section
Citation Check
License
Please find the rights and licenses in JIF (Jurnal Ilmu Fisika).
1. License
The non-commercial use of the article will be governed by the Creative Commons Attribution license as currently displayed on Creative Commons Attribution-NonCommercial 4.0 International License.
2. Author's Warranties
The author warrants that the article is original, written by stated author(s), has not been published before, contains no unlawful statements, does not infringe the rights of others, is subject to copyright that is vested exclusively in the author and free of any third party rights, and that any necessary written permissions to quote from other sources have been obtained by the author(s).
3. User Rights
JIF's spirit is to disseminate articles published are as free as possible. Under the Creative Commons license, JIF permits users to copy, distribute, display, and perform the work for non-commercial purposes only. Users will also need to attribute authors and JIF on distributing works in the journal.
4. Rights of Authors
Authors retain the following rights:
- Copyright, and other proprietary rights relating to the article, such as patent rights,
- The right to use the substance of the article in future own works, including lectures and books,
- The right to reproduce the article for own purposes, provided the copies are not offered for sale,
- The right to self-archive the article.
5. Co-Authorship
If the article was jointly prepared by other authors, the signatory of this form warrants that he/she has been authorized by all co-authors to sign this agreement on their behalf, and agrees to inform his/her co-authors of the terms of this agreement.
6. Termination
This agreement can be terminated by the author or JIF upon two months's notice where the other party has materially breached this agreement and failed to remedy such breach within a month of being given the terminating party's notice requesting such breach to be remedied. No breach or violation of this agreement will cause this agreement or any license granted in it to terminate automatically or affect the definition of JIF.
7. Royalties
This agreement entitles the author to no royalties or other fees. To such extent as legally permissible, the author waives his or her right to collect royalties relative to the article in respect of any use of the article by JIF or its sublicensee.
8. Miscellaneous
JIF will publish the article (or have it published) in the journal if the article's editorial process is successfully completed and JIF or its sublicensee has become obligated to have the article published. JIF may conform the article to a style of punctuation, spelling, capitalization, referencing and usage that it deems appropriate. The author acknowledges that the article may be published so that it will be publicly accessible and such access will be free of charge for the readers.
